Institute of Physiology - Publications

Mechanisms of Post-Pancreatitis Diabetes Mellitus and Cystic Fibrosis-Related Diabetes: A Review of Preclinical Studies

By Institute of Physiology on 25. 10. 2021
Authors: Eleonora Gal, Jurij Dolenšek, Andraž Stožer, Laszlo Czako, Attila Ebert, Viktoria Venglovecz
Journal: Frontiers in Endocrinology
https://doi.org/10.3389/fendo.2021.715043

Anatomical proximity and functional correlations between the exocrine and endocrine pancreas warrant reciprocal effects between the two parts. Inflammatory diseases of the exocrine pancreas, such as acute or chronic pancreatitis, or the presence of cystic fibrosis disrupt endocrine function,...

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In Vitro Culturing of Adult Stem Cells: The Importance of Serum and Atmospheric Oxygen

By Institute of Physiology on 27. 08. 2021
Authors: Maša Čater, Gregor Majdič
Journal: Advances in experimental medicine and biology
https://doi.org/10.1007/5584_2021_656

Adult stem cells are undifferentiated cells found in many different tissues in the adult human and animal body and are thought to be important for replacing damaged and dead cells during life. Due to their differentiation abilities, they have significant potential for regeneration and...

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Glucose-dependent activation, activity, and deactivation of beta cell networks in acute mouse pancreas tissue slices

By Institute of Physiology on 21. 07. 2021
Authors: Andraž Stožer, Maša Skelin Klemen, Marko Gosak, Lidija Križančić Bombek, Viljem Pohorec, Marjan Slak Rupnik, Jurij Dolenšek
Journal: American Journal of Physiology - Endocrinology and Metabolism
https://doi.org/10.1152/ajpendo.00043.2021

Many details of glucose-stimulated intracellular calcium changes in beta cells during activation, activity, and deactivation, as well as their concentration-dependence, remain to be analyzed. Classical physiological experiments indicated that in islets, functional differences between...

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Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets

By Institute of Physiology on 16. 06. 2021
Authors: Okka Scholz, Silke Otter, Alena Welters, Laura Wörmeyer, Jurij Dolenšek, Maša Skelin Klemen, Viljem Pohorec, Daniel Eberhard, Jessica Mrugala, Anna Hamacher, Angela Koch, Miguel Sanz, Torsten Hoffman, Jens Hogeback, Diran Herebian, Nikolaj Klöcker, Alexander Piechot, Ertan Mayatepek, Thomas Meissner, Andraž Stožer, Eckhard Lammert
Journal: Cell Chemical Biology
https://doi.org/10.1016/j.chembiol.2021.05.011

Dextromethorphan (DXM) acts as cough suppressant via its central action. Cell-protective effects of this drug have been reported in peripheral tissues, making DXM potentially useful for treatment of several common human diseases, such as type 2 diabetes mellitus (T2DM). Pancreatic islets are...

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