Institute of Physiology - Publications

Glucose-dependent activation, activity, and deactivation of beta cell networks in acute mouse pancreas tissue slices

By Institute of Physiology on 21. 07. 2021
Authors: Andraž Stožer, Maša Skelin Klemen, Marko Gosak, Lidija Križančić Bombek, Viljem Pohorec, Marjan Slak Rupnik, Jurij Dolenšek
Journal: American Journal of Physiology - Endocrinology and Metabolism
https://doi.org/10.1152/ajpendo.00043.2021

Many details of glucose-stimulated intracellular calcium changes in beta cells during activation, activity, and deactivation, as well as their concentration-dependence, remain to be analyzed. Classical physiological experiments indicated that in islets, functional differences between...

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Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets

By Institute of Physiology on 16. 06. 2021
Authors: Okka Scholz, Silke Otter, Alena Welters, Laura Wörmeyer, Jurij Dolenšek, Maša Skelin Klemen, Viljem Pohorec, Daniel Eberhard, Jessica Mrugala, Anna Hamacher, Angela Koch, Miguel Sanz, Torsten Hoffman, Jens Hogeback, Diran Herebian, Nikolaj Klöcker, Alexander Piechot, Ertan Mayatepek, Thomas Meissner, Andraž Stožer, Eckhard Lammert
Journal: Cell Chemical Biology
https://doi.org/10.1016/j.chembiol.2021.05.011

Dextromethorphan (DXM) acts as cough suppressant via its central action. Cell-protective effects of this drug have been reported in peripheral tissues, making DXM potentially useful for treatment of several common human diseases, such as type 2 diabetes mellitus (T2DM). Pancreatic islets are...

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Socio-demographic and health factors drive the epidemic progression and should guide vaccination strategies for best COVID-19 containment

By Institute of Physiology on 16. 06. 2021
Authors: Rene Markovič, Marko Šterk, Marko Marhl, Matjaž Perc, Marko Gosak
Journal: Results in Physics
https://doi.org/10.1016/j.rinp.2021.104433

We propose and study an epidemiological model on a social network that takes into account heterogeneity of the population and different vaccination strategies. In particular, we study how the COVID-19 epidemics evolves and how it is contained by different vaccination scenarios by taking into...

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Collective Sensing of β-Cells Generates the Metabolic Code

By Institute of Physiology on 29. 05. 2021
Authors: Dean Korošak, Marjan Slak Rupnik
Journal: Frontiers in Physiology
https://doi.org/10.3389/fphys.2018.00031

Major part of a pancreatic islet is composed of β-cells that secrete insulin, a key hormone regulating influx of nutrients into all cells in a vertebrate organism to support nutrition, housekeeping or energy storage. β-cells constantly communicate with each other using both direct,...

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