Authors: Maja Duh, Marko Gosak, Matjaž Perc
Journal: Chaos, Solitons & Fractals
Understanding the evolution of cooperation in structured populations remains one of the fundamental challenges of the 21st century, with far-reaching implications for the wellbeing of modern human societies. Studies over the past two decades showed that the structure of the network of...
Authors: Maša Čater, Gregor Majdič
Journal: European Journal of Neuroscience
Early life stress can adversely influence brain development and reprogram brain function and consequently behavior in adult life. Adequate maternal care in early childhood is therefore particularly important for the normal brain development, and adverse early life experiences can lead to...
Assessing the origin and velocity of Ca2+ waves in three-dimensional tissue: Insights from a mathematical model and confocal imaging in mouse pancreas tissue slicesBy Institute of Physiology on 26. 02. 2021
Authors: Marko Šterk, Jurij Dolenšek, Lidija Križančić Bombek, Rene Markovič, Darko Zakelšek, Matjaž Perc, Viljem Pohorec, Andraž Stožer, Marko Gosak
Journal: Communications in Nonlinear Science and Numerical Simulation
Many tissues are gap-junction-coupled syncytia that support cell-to-cell communication via propagating calcium waves. This also holds true for pancreatic islets of Langerhans, where several thousand beta cells work in synchrony to ensure proper insulin secretion. Two emerging functional...
Flexibility of enzymatic transitions as a hallmark of optimized enzyme steady-state kinetics and thermodynamicsBy Institute of Physiology on 26. 02. 2021
Authors: Marko Šterk, Rene Markovič, Marko Marhl, Aleš Fajmut, Andrej Dobovišek
Journal: Computational Biology and Chemistry
We investigate the relations between the enzyme kinetic flexibility, the rate of entropy production, and the Shannon information entropy in a steady-state enzyme reaction. All these quantities are maximized with respect to enzyme rate constants. We show that the steady-state, which is...